Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

doi:10.1128/AAC.49.7.2575-2582.2005

Review

. 2005 Jul;49(7):2575-82.

doi: 10.1128/AAC.49.7.2575-2582.2005.

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Mark A Winters¹, Thomas C Merigan

Affiliations

Affiliation

¹ Division of Infectious Diseases and Geographic Medicine, Stanford University, 300 Pasteur Drive, Room S-146, Stanford, California 94305-5107, USA. mark.winters@stanford.edu

PMID: 15980322
PMCID: PMC1168704
DOI: 10.1128/AAC.49.7.2575-2582.2005

Review

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Mark A Winters et al. Antimicrob Agents Chemother. 2005 Jul.

. 2005 Jul;49(7):2575-82.

doi: 10.1128/AAC.49.7.2575-2582.2005.

Authors

Mark A Winters¹, Thomas C Merigan

Affiliation

¹ Division of Infectious Diseases and Geographic Medicine, Stanford University, 300 Pasteur Drive, Room S-146, Stanford, California 94305-5107, USA. mark.winters@stanford.edu

PMID: 15980322
PMCID: PMC1168704
DOI: 10.1128/AAC.49.7.2575-2582.2005

No abstract available

PubMed Disclaimer

Figures

**FIG. 1.**
Locations of inserts in the protein structures of RT (A) and PR (B) enzymes. (The RT structure is adapted from reference with permission of the publisher.)

See this image and copyright information in PMC

Cited by

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors.
Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. Al-Gharabli SI, et al. Chembiochem. 2006 Jul;7(7):1048-55. doi: 10.1002/cbic.200500533. Chembiochem. 2006. PMID: 16688706 Free PMC article.
In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.
Li Z, Terry B, Olds W, Protack T, Deminie C, Minassian B, Nowicka-Sans B, Sun Y, Dicker I, Hwang C, Lataillade M, Hanna GJ, Krystal M. Li Z, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5500-8. doi: 10.1128/AAC.01195-13. Epub 2013 Aug 26. Antimicrob Agents Chemother. 2013. PMID: 23979732 Free PMC article.
Current and Novel Inhibitors of HIV Protease.
Pokorná J, Machala L, Rezáčová P, Konvalinka J. Pokorná J, et al. Viruses. 2009 Dec;1(3):1209-39. doi: 10.3390/v1031209. Epub 2009 Dec 11. Viruses. 2009. PMID: 21994591 Free PMC article.
Management of Antiretroviral Therapy with Boosted Protease Inhibitors-Darunavir/Ritonavir or Darunavir/Cobicistat.
Marin RC, Behl T, Negrut N, Bungau S. Marin RC, et al. Biomedicines. 2021 Mar 18;9(3):313. doi: 10.3390/biomedicines9030313. Biomedicines. 2021. PMID: 33803812 Free PMC article. Review.
Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.
Sasková KG, Kozísek M, Rezácová P, Brynda J, Yashina T, Kagan RM, Konvalinka J. Sasková KG, et al. J Virol. 2009 Sep;83(17):8810-8. doi: 10.1128/JVI.00451-09. Epub 2009 Jun 17. J Virol. 2009. PMID: 19535439 Free PMC article.

See all "Cited by" articles

References

1. Alexander, L., M. J. Aquino-DeJesus, M. Chan, and W. A. Andiman. 2002. Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child. J. Virol. 76:10533-10539. - PMC - PubMed
1. Bally, F., R. Martinez, S. Peters, P. Sudre, and A. Telenti. 2000. Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retrovir. 16:1209-1213. - PubMed
1. Bebenek, K., J. Abbotts, S. H. Wilson, and T. A. Kunkel. 1993. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J. Biol. Chem. 268:10324-10334. - PubMed
1. Bonfanti, P., L. Valsecchi, F. Parazzini, S. Carradori, L. Pusterla, P. Fortuna, L. Timillero, F. Alessi, G. Ghiselli, A. Gabbuti, E. Di Cintio, C. Martinelli, I. Faggion, S. Landonio, T. Quirino, et al. 2000. Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. AIDS 23:236-245. - PubMed
1. Boyer, P. L., T. Imamichi, S. G. Sarafianos, E. Arnold, and S. H. Hughes. 2004. Effects of the delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. J. Virol. 78:9987-9997. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Alexander, L., M. J. Aquino-DeJesus, M. Chan, and W. A. Andiman. 2002. Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child. J. Virol. 76:10533-10539. - PMC - PubMed

[2] Alexander, L., M. J. Aquino-DeJesus, M. Chan, and W. A. Andiman. 2002. Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child. J. Virol. 76:10533-10539. - PMC - PubMed

[3] Bally, F., R. Martinez, S. Peters, P. Sudre, and A. Telenti. 2000. Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retrovir. 16:1209-1213. - PubMed

[4] Bally, F., R. Martinez, S. Peters, P. Sudre, and A. Telenti. 2000. Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retrovir. 16:1209-1213. - PubMed

[5] Bebenek, K., J. Abbotts, S. H. Wilson, and T. A. Kunkel. 1993. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J. Biol. Chem. 268:10324-10334. - PubMed

[6] Bebenek, K., J. Abbotts, S. H. Wilson, and T. A. Kunkel. 1993. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J. Biol. Chem. 268:10324-10334. - PubMed

[7] Bonfanti, P., L. Valsecchi, F. Parazzini, S. Carradori, L. Pusterla, P. Fortuna, L. Timillero, F. Alessi, G. Ghiselli, A. Gabbuti, E. Di Cintio, C. Martinelli, I. Faggion, S. Landonio, T. Quirino, et al. 2000. Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. AIDS 23:236-245. - PubMed

[8] Bonfanti, P., L. Valsecchi, F. Parazzini, S. Carradori, L. Pusterla, P. Fortuna, L. Timillero, F. Alessi, G. Ghiselli, A. Gabbuti, E. Di Cintio, C. Martinelli, I. Faggion, S. Landonio, T. Quirino, et al. 2000. Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. AIDS 23:236-245. - PubMed

[9] Boyer, P. L., T. Imamichi, S. G. Sarafianos, E. Arnold, and S. H. Hughes. 2004. Effects of the delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. J. Virol. 78:9987-9997. - PMC - PubMed

[10] Boyer, P. L., T. Imamichi, S. G. Sarafianos, E. Arnold, and S. H. Hughes. 2004. Effects of the delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. J. Virol. 78:9987-9997. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Affiliation

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Authors

Affiliation

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical