Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Jul;49(7):2575-82.
doi: 10.1128/AAC.49.7.2575-2582.2005.

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Mark A Winters  1 , Thomas C Merigan
Affiliations
Review

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms

Mark A Winters et al. Antimicrob Agents Chemother. 2005 Jul.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Locations of inserts in the protein structures of RT (A) and PR (B) enzymes. (The RT structure is adapted from reference with permission of the publisher.)
See this image and copyright information in PMC

References

    1. Alexander, L., M. J. Aquino-DeJesus, M. Chan, and W. A. Andiman. 2002. Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child. J. Virol. 76:10533-10539. - PMC - PubMed
    1. Bally, F., R. Martinez, S. Peters, P. Sudre, and A. Telenti. 2000. Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retrovir. 16:1209-1213. - PubMed
    1. Bebenek, K., J. Abbotts, S. H. Wilson, and T. A. Kunkel. 1993. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J. Biol. Chem. 268:10324-10334. - PubMed
    1. Bonfanti, P., L. Valsecchi, F. Parazzini, S. Carradori, L. Pusterla, P. Fortuna, L. Timillero, F. Alessi, G. Ghiselli, A. Gabbuti, E. Di Cintio, C. Martinelli, I. Faggion, S. Landonio, T. Quirino, et al. 2000. Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. AIDS 23:236-245. - PubMed
    1. Boyer, P. L., T. Imamichi, S. G. Sarafianos, E. Arnold, and S. H. Hughes. 2004. Effects of the delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. J. Virol. 78:9987-9997. - PMC - PubMed

MeSH terms