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. 2005 Jul;49(7):3025-7.
doi: 10.1128/AAC.49.7.3025-3027.2005.

In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles

Anne-Marie Le Ray  1 , Hélène Gautier, Marie-Katel Laty, Guy Daculsi, Christian Merle, Cédric Jacqueline, Antoine Hamel, Jocelyne Caillon
Affiliations

In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles

Anne-Marie Le Ray et al. Antimicrob Agents Chemother. 2005 Jul.

Abstract

Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.

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Figures

FIG. 1.
FIG. 1.
Cumulated release rates of vancomycin after dissolution test. ⋄, microbiological assay; □, HPLC assay. Error bars represent standard deviations.
FIG. 2.
FIG. 2.
Bactericidal activity of vancomycin alone and dispersed in microparticles. ⋄, control; ♦, control plus unloaded MP; 218, loaded MP; ▪, vancomycin plus unloaded MP; □, vancomycin.
See this image and copyright information in PMC

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