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Comparative Study
. 2005 Jul;49(7):3028-30.
doi: 10.1128/AAC.49.7.3028-3030.2005.

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Joan Gavaldà  1 , María-Teresa Martín, Pedro López, Xavier Gomis, José-Luís Ramírez, Dolors Rodríguez, Oscar Len, Yolanda Puigfel, Isabel Ruíz, Albert Pahissa
Affiliations
Comparative Study

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Joan Gavaldà et al. Antimicrob Agents Chemother. 2005 Jul.

Abstract

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.

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Figures

FIG. 1.
FIG. 1.
Effects of administration of nebulized d-AMB versus intravenous administration of d-AMB in steroid-immunosuppressed rats with experimental invasive aspergillosis. *, significant relative to value for control.
FIG. 2.
FIG. 2.
Effects of administration of nebulized L-AMB versus intravenous administration of L-AMB in steroid-immunosuppressed rats with experimental invasive aspergillosis. *, significant relative to value for control; †, significant relative to value for i.v. d-AMB; ‡, significant relative to value for nd-AMB.
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