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. 2005 Jul 6;127(26):9342-3.
doi: 10.1021/ja052049g.

Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization

Jianglong Zhu  1 , Nicholas P Grigoriadis, Jonathan P Lee, John A Porco Jr
Affiliations

Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization

Jianglong Zhu et al. J Am Chem Soc. .

Abstract

An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.

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