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. 2005;4(2):8.
doi: 10.1186/jbiol27. Epub 2005 Jun 27.

Movement in ribosome translocation

Christopher S Fraser  1 , John W B Hershey
Affiliations

Movement in ribosome translocation

Christopher S Fraser et al. J Biol. 2005.

Abstract

Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G.GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.

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Figures

Figure 1
Figure 1
The pathway of translocation. The tRNAs are shown as colored bars, some with attached amino acids depicted as circles colored to correspond to their tRNAs. The reactions in the pathway are described in the text; the mRNA and bound EF-G are not shown.
See this image and copyright information in PMC

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References

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