doi: 10.1016/j.apradiso.2005.04.008.
Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies
Affiliations
- PMID: 15985372
- DOI: 10.1016/j.apradiso.2005.04.008
Item in Clipboard
Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies
Appl Radiat Isot.
2005 Sep.
Abstract
The fluorine-18 labeled dopamine transport (DAT) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [(18)F]FECNT in a 16% decay corrected yield. This method utilizes a new [(18)F]fluoralkylating agent and provides high purity [(18)F]FECNT in a formulation suitable for human use.
Similar articles
-
Potential of [(18)F]beta-CFT-FE (2beta-carbomethoxy-3beta-(4-fluorophenyl)-8-(2-[(18)F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain.Synapse. 2004 Oct;54(1):37-45. doi: 10.1002/syn.20059. Synapse. 2004. PMID: 15300883
-
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.J Med Chem. 2003 Mar 13;46(6):925-35. doi: 10.1021/jm0100180. J Med Chem. 2003. PMID: 12620070
-
18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.Nucl Med Biol. 2000 Jan;27(1):1-12. doi: 10.1016/s0969-8051(99)00080-3. Nucl Med Biol. 2000. PMID: 10755640
-
Tropane-derived (11) C-labelled and (18) F-labelled DAT ligands.J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):149-58. doi: 10.1002/jlcr.3018. J Labelled Comp Radiopharm. 2013. PMID: 24285320 Review.
-
Fluorinase: a tool for the synthesis of ¹⁸F-labeled sugars and nucleosides for PET.Future Med Chem. 2009 Aug;1(5):865-73. doi: 10.4155/fmc.09.74. Future Med Chem. 2009. PMID: 21426085 Review.
Cited by
-
Strained Ammonium Precursors for Radiofluorinations.ChemistryOpen. 2022 Jun;11(6):e202200039. doi: 10.1002/open.202200039. ChemistryOpen. 2022. PMID: 35736542 Free PMC article. Review.
-
Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.Nucl Med Biol. 2008 Jul;35(5):615-22. doi: 10.1016/j.nucmedbio.2008.04.003. Nucl Med Biol. 2008. PMID: 18589306 Free PMC article.
-
Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors.Bioorg Med Chem. 2012 Apr 15;20(8):2721-38. doi: 10.1016/j.bmc.2012.02.019. Epub 2012 Feb 25. Bioorg Med Chem. 2012. PMID: 22425346 Free PMC article.
-
Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.PET Clin. 2009 Jan;4(1):101-28. doi: 10.1016/j.cpet.2009.05.006. PET Clin. 2009. PMID: 20216936 Free PMC article.
-
Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans.Nucl Med Biol. 2014 Mar;41(3):217-22. doi: 10.1016/j.nucmedbio.2013.12.013. Epub 2013 Dec 26. Nucl Med Biol. 2014. PMID: 24533985 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
