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. 2005 Sep;63(3):353-61.
doi: 10.1016/j.apradiso.2005.04.008.

Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies

Ronald J Voll  1 , Jonathan McConathy, Michael S Waldrep, Ronald J Crowe, Mark M Goodman
Affiliations

Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies

Ronald J Voll et al. Appl Radiat Isot. 2005 Sep.

Abstract

The fluorine-18 labeled dopamine transport (DAT) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [(18)F]FECNT in a 16% decay corrected yield. This method utilizes a new [(18)F]fluoralkylating agent and provides high purity [(18)F]FECNT in a formulation suitable for human use.

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