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• High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis.

  Cao Y, Yang J, Colby K, Hogan SL, Hu Y, Jennette CE, Berg EA, Zhang Y, Jennette JC, Falk RJ, Preston GA. Cao Y, et al. PLoS One. 2012;7(8):e42783. doi: 10.1371/journal.pone.0042783. Epub 2012 Aug 3. PLoS One. 2012. PMID: 22880107 Free PMC article.
• Functional single nucleotide polymorphism-based association studies.

  Carlton VE, Ireland JS, Useche F, Faham M. Carlton VE, et al. Hum Genomics. 2006 Jun;2(6):391-402. doi: 10.1186/1479-7364-2-6-391. Hum Genomics. 2006. PMID: 16848977 Free PMC article. Review.
• Associations between the PTPN22 1858C->T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis: results from a 10-year longitudinal study.

  Lie BA, Viken MK, Odegård S, van der Heijde D, Landewé R, Uhlig T, Kvien TK. Lie BA, et al. Ann Rheum Dis. 2007 Dec;66(12):1604-9. doi: 10.1136/ard.2006.067892. Epub 2007 May 1. Ann Rheum Dis. 2007. PMID: 17472988 Free PMC article.
• PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.

  Johansson M, Arlestig L, Hallmans G, Rantapää-Dahlqvist S. Johansson M, et al. Arthritis Res Ther. 2006;8(1):R19. doi: 10.1186/ar1868. Arthritis Res Ther. 2006. PMID: 16507117 Free PMC article.
• Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients.

  Pierer M, Kaltenhäuser S, Arnold S, Wahle M, Baerwald C, Häntzschel H, Wagner U. Pierer M, et al. Arthritis Res Ther. 2006;8(3):R75. doi: 10.1186/ar1945. Epub 2006 Apr 24. Arthritis Res Ther. 2006. PMID: 16635271 Free PMC article.