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Editorial
. 2005 Jun;9(3):257-8.
doi: 10.1186/cc3720. Epub 2005 May 5.

Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections?

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Editorial

Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections?

Heiman F L Wertheim et al. Crit Care. 2005 Jun.

Abstract

In a retrospective study, Dr Muller and colleagues have assessed the efficacy of mupirocin nasal ointment alongside hygienic measures in methicillin-resistant Staphylococcus aureus (MRSA)-positive patients admitted to the intensive care unit (ICU). Their findings, which suggest that intranasal mupirocin can prevent ICU-related MRSA infections, need confirmation in a well-designed clinical trial. In general: early identification, isolation and treatment of all MRSA carriers, including health care workers, and disinfection of contaminated environments, are the main 'ingredients' of an effective MRSA 'search and destroy' program.

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References

    1. Muller AA, Talon D, Potier A, Belle A, Cappelier G, Bertrand X. Use of intranasal mupirocin to prevent MRSA infection in intensive care units. Crit Care. 2005;9:R246–R250. doi: 10.1186/cc3512. - DOI - PMC - PubMed
    1. Pujol M, Pena C, Pallares R, Ariza J, Ayats J, Dominguez MA, Gudiol F. Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med. 1996;100:509–516. doi: 10.1016/S0002-9343(96)00014-9. - DOI - PubMed
    1. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis. 2003;36:53–59. doi: 10.1086/345476. - DOI - PubMed
    1. Perl TM, Cullen JJ, Wenzel RP, Zimmerman MB, Pfaller MA, Sheppard D, Twombley J, French PP, Herwaldt LA. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med. 2002;346:1871–1877. doi: 10.1056/NEJMoa003069. - DOI - PubMed
    1. Kalmeijer MD, Coertjens H, Van Nieuwland-Bollen PM, Bogaers-Hofman D, De Baere GA, Stuurman A, Van Belkum A, Kluytmans JA. Surgical site infections in orthopedic surgery: the effect of mupirocin nasal ointment in a double-blind, randomized, placebo-controlled study. Clin Infect Dis. 2002;35:353–358. doi: 10.1086/341025. - DOI - PubMed

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