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Review
. 2005 Jul 1;121(7):963-5.
doi: 10.1016/j.cell.2005.06.018.

Life, death, and ubiquitin: taming the mule

Ayelet Shmueli  1 , Moshe Oren
Affiliations
Free article
Review

Life, death, and ubiquitin: taming the mule

Ayelet Shmueli et al. Cell. .
Free article

Abstract

Ubiquitin-mediated protein degradation is an efficient way for the cell to get rid of unwanted proteins. A key player in this process is the E3 ubiquitin ligase. In this issue of Cell, and describe a new E3 ligase, ARF-BP1/Mule, which targets two very different substrates, p53 and Mcl-1, with completely different cellular outcomes.

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