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. 2005 Sep 1;15(17):3870-3.
doi: 10.1016/j.bmcl.2005.05.117.

Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Xiaojun Han  1 , Jodi A Michne, Sokhom S Pin, Kevin D Burris, Lynn A Balanda, Lawrence K Fung, Tracey Fiedler, Kaitlin E Browman, Matthew T Taber, Jie Zhang, Gene M Dubowchik
Affiliations

Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Xiaojun Han et al. Bioorg Med Chem Lett. .

Abstract

7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.

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