Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Sep;17(9):1052-62.
doi: 10.1016/j.cellsig.2005.03.002. Epub 2005 Apr 7.

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

Jesús Balsinde  1 , María A Balboa
Affiliations
Review

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

Jesús Balsinde et al. Cell Signal. 2005 Sep.

Abstract

Mammalian cells contain several calcium-independent phospholipase A2 (PLA2) enzymes. The best studied of them is the so-called Group VIA PLA2 (iPLA2-VIA), which is an 85-88 kDa enzyme with unique structural features among the PLA2 superfamily of enzymes, and has been found to play a key role in homeostatic membrane phospholipid metabolism in various cell types. Growing evidence suggests that, in addition to its homeostatic function, iPLA2-VIA may also play distinct roles in cellular signaling. This review focuses on the biochemical mechanisms that regulate the activity of iPLA2-VIA in activated cells, and the biological functions proposed for this enzyme during stimulus-response coupling.

PubMed Disclaimer

Publication types

LinkOut - more resources