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Clinical Trial
. 2006 Dec;21(8):544-7.
doi: 10.1016/j.eurpsy.2005.04.003. Epub 2005 Jul 1.

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Marijn Lijffijt  1 , J Leon Kenemans, Annemiek ter Wal, Elise H Quik, C Kemner, Herman Westenberg, Marinus N Verbaten, Herman van Engeland
Affiliations
Clinical Trial

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Marijn Lijffijt et al. Eur Psychiatry. 2006 Dec.

Abstract

Purpose: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.

Subjects and methods: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.

Results: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.

Discussion and conclusion: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

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