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. 1992 Jun;35(6):688-93.
doi: 10.1002/art.1780350614.

Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis

F M Wigley  1 , R A Wise, R Miller, B W Needleman, R J Spence
Affiliations

Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis

F M Wigley et al. Arthritis Rheum. 1992 Jun.

Abstract

Objective: To determine the clinical and serologic risk factors for digital ischemic events in patients with systemic sclerosis (SSc).

Methods: Retrospective review of clinical and laboratory data and review of current clinical status of 98 patients with SSc, seen between 1985 and 1990.

Results: Amputation of 1 or more digits due to ischemia occurred in 20.4% of the patients; 9.2% had multiple digit loss. Sclerodactyly alone and anticentromere antibody (ACA) were associated with loss of 1 or more digits. Age, smoking status, duration of disease, or duration of Raynaud's phenomenon were not predictive for loss of digits.

Conclusion: Patients with limited SSc who are positive for ACA have an increased risk of major peripheral vascular occlusive disease.

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Comment in

  • Of names and abbreviations.
    Gonzalez EB. Gonzalez EB. Arthritis Rheum. 1993 Feb;36(2):285-7. doi: 10.1002/art.1780360232. Arthritis Rheum. 1993. PMID: 8431224 No abstract available.

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