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. 2005 Aug 1;192(3):492-6.
doi: 10.1086/431514. Epub 2005 Jun 23.

Subtype C Is associated with increased vaginal shedding of HIV-1

Grace C John-Stewart  1 , Ruth W Nduati, Christine M Rousseau, Dorothy A Mbori-Ngacha, Barbra A Richardson, Stephanie Rainwater, Dana D Panteleeff, Julie Overbaugh
Affiliations

Subtype C Is associated with increased vaginal shedding of HIV-1

Grace C John-Stewart et al. J Infect Dis. .

Abstract

The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1.

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Conflict of interest statement

Potential conflicts of interest: none reported.

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