Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jul;32(7):1258-61.

Falsely elevated cardiac troponin-I in patients with seropositive rheumatoid arthritis

Patrick R Kenny  1 , David R Finger
Affiliations
  • PMID: 15996061

Falsely elevated cardiac troponin-I in patients with seropositive rheumatoid arthritis

Patrick R Kenny et al. J Rheumatol. 2005 Jul.

Abstract

Objective: To determine if patients with seropositive rheumatoid arthritis (RA) have abnormally elevated concentrations of cardiac troponin-I (cTnI). Reports suggest the presence of serum rheumatoid factor (RF) may interfere with the cTnI assay, leading to falsely elevated cTnI levels. One study reported a falsely elevated cTnI in 15 out of 100 serum samples with elevated RF using the Abbott assay, but no elevated level using the Bayer assay. It is unclear how many of these samples came from patients with RA.

Methods: Serum samples were drawn from 60 patients with seropositive RA. We measured RF and cTnI levels using both the Abbott AxSYM assay and the Bayer ADVIA Centaur assay.

Results: Of 60 RA patients with RF ranging from 15 to 2724 IU/ml, none was found to have an elevated cTnI on either assay.

Conclusion: Using 2 commercial assays for cTnI, we found that patients with seropositive RA do not have falsely elevated serum cTnI levels.

PubMed Disclaimer

Publication types

LinkOut - more resources