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Review
. 2005 Aug;5(8):1789-92.
doi: 10.1111/j.1600-6143.2005.00970.x.

Granulysin: a novel host defense molecule

Alan M Krensky  1 , Carol Clayberger
Affiliations
Free article
Review

Granulysin: a novel host defense molecule

Alan M Krensky et al. Am J Transplant. 2005 Aug.
Free article

Abstract

Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

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