Review
doi: 10.1055/s-2005-870150.
HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome
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- PMID: 16001331
- DOI: 10.1055/s-2005-870150
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Review
HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome
Horm Metab Res.
2005 Jun.
Abstract
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.
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