Comparison of electrophysiological models for human ventricular cells and tissues

Abstract

In this paper we briefly review currently published models for human ventricular cells and tissues. We discuss the Priebe-Beuckelmann (PB) model and the reduced version of this model constructed by Bernus et al. (redPB), the Ten Tusscher-Noble-Noble-Panfilov (TNNP) model and the Iyer-Mazhari-Winslow (IMW) model. We compare several characteristics of these models such as: sources of experimental data the models are based on, action potential morphology, action potential duration (APD) and conduction velocity (CV) restitution and computational efficiency. Finally, we discuss the application of a subset of these models-the redPB and the TNNP model-to study simulated spiral wave dynamics in 2D tissue sheets and in the human ventricles. We discuss the suitability of the different models for particular research questions and their limitations.