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Comment
. 2005 Jul 9;331(7508):109-10.
doi: 10.1136/bmj.331.7508.109-b.

Participants in research: routine extrapolation of randomised controlled trials is absurd

Bruce G Charlton
Comment

Participants in research: routine extrapolation of randomised controlled trials is absurd

Bruce G Charlton. BMJ. .
No abstract available

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Comment on

  • Participants in research.
    Sackett DL. Sackett DL. BMJ. 2005 May 21;330(7501):1164. doi: 10.1136/bmj.330.7501.1164. BMJ. 2005. PMID: 15905233 Free PMC article. No abstract available.

References

    1. Charlton B, Miles A. The rise and fall of EBM. Q J Med 1998;91: 371-4. - PubMed
    1. Sackett DL. Participants in research. BMJ 2005;330: 1164. (21 May.) - PMC - PubMed
    1. Charlton BG. Fundamental deficiencies in the megatrial methodology. Curr Contr Trials Cardiovasc Med 2001;2: 2-7. - PMC - PubMed
    1. Bradford Hill AB, Hill ID. Bradford Hill's principles of medical statistics. London: Edward Arnold, 1991.
    1. Charlton BG, Taylor PRA, Proctor SJ. The PACE (population-adjusted clinical epidemiology) strategy: a new approach to multi-centred clinical research. Q J Med 1997;90: 147-51. - PubMed