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Comparative Study
. 2006 Jun 8;237(1):143-54.
doi: 10.1016/j.canlet.2005.05.040. Epub 2005 Jul 11.

SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

Ji Kon Ryu  1 , Woo Jin Lee, Kwang Hyuck Lee, Jin-Hyeok Hwang, Yong-Tae Kim, Yong Bum Yoon, Chung Yong Kim
Affiliations
Comparative Study

SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

Ji Kon Ryu et al. Cancer Lett. .

Abstract

A novel hybrid synthetic histone deacetylase inhibitor, SK-7041, was synthesized from hydroaxamic acid of trichostatin A (TSA) and pyridyl ring of MS-275. TSA and SK-7041 both induced apoptosis and G2-M cell cycle arrest in pancreatic cancer cell lines. The expressions of p21 and cyclin D2 were up-regulated and that of cyclin B1 was down-regulated by TSA or SK-7041. The expression levels of Mcl-1 and Bcl-XL but not those of Bcl-2, Bax, and Bak were suppressed by TSA or SK-7041 treatment. SK-7041 or TSA induced apoptosis and G2-M cell cycle arrest by up-regulating p21 and down-regulating cyclin B1, Mcl-1, and Bcl-XL.

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