Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2005 Nov;54(11):1579-84.
doi: 10.1136/gut.2005.064212. Epub 2005 Jul 11.

Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease

C E Todhunter  1 , A Sutherland-Craggs, S A Bartram, P T Donaldson, A K Daly, R M Francis, J C Mansfield, N P Thompson
Affiliations
Multicenter Study

Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease

C E Todhunter et al. Gut. 2005 Nov.

Abstract

Background: Osteoporosis is an important cause of morbidity in patients with Crohn's disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis.

Aim: To investigate the influence of interleukin 6 (IL-6), collagen type 1alpha1 (COL1A1), and vitamin D receptor gene (VDR) single nucleotide polymorphisms (SNP) on BMD in patients with Crohn's disease.

Patients: A cohort of 245 well characterised patients with Crohn's disease were recruited from the inflammatory bowel disease register at the Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne, and the Queen Elizabeth Hospital, Gateshead, UK.

Methods: Patients were genotyped for IL-6 C-174G SNP, COL1A1 Sp1 binding site G T SNP, VDR Taq1, and Fok1 SNPs, and CARD15 R702W, G908R, and L1007fs SNPs. BMD was measured at the lumbar spine (LSP) and hip using dual energy x ray absorptiometry.

Results: A total of 158 female and 87 male patients, aged 24-70 years (mean 44), were recruited. There were no significant differences in the distribution of the tested SNPs when analysed for age, body mass index, pre/post-menopausal status, smoking, or steroid use. Two hundred and thirteen patients were genotyped for the IL-6 SNP. LSP and total hip BMD was significantly lower in patients with the GG genotype (48%) than the CC genotype (15%) (p = 0.041, p = 0.014). One hundred and eighty patients were genotyped for the COL1A1 SNP. There was no significant difference in BMD at LSP. Hip BMD was significantly lower in heterozygous patients compared with homozygous wild-types (p = 0.034). There were no significant differences in BMD between genotypes for the two VDR SNPs or the CARD15 genotypes examined.

Conclusion: IL-6 and COL1A1 gene polymorphisms influence BMD in patients with Crohn's disease but the particular VDR gene polymorphisms studied do not have a major effect.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean bone mineral density (BMD) in the different interleukin 6 (IL-6) genotype groups. 95% CI, 95% confidence interval.
Figure 2
Figure 2
Mean total hip bone mineral density (BMD) in the different collagen type 1α1 (COL1A1) genotype groups. 95% CI, 95% confidence interval.
See this image and copyright information in PMC

References

    1. Klaus J, Armbrect G, Steinkamp M, et al. High prevalence of osteoporotic vertebral fractures in patients with Crohn’s disease. Gut 2002;51:654–8. - PMC - PubMed
    1. Vestergaard P, Krogh K, Rejnmark L, et al. Fracture risk is increased in Crohn’s disease, but not in ulcerative colitis. Gut 2000;46:176–81. - PMC - PubMed
    1. van Staa TP, Cooper C, Brusse LS, et al. Inflammatory bowel disease and the risk of fracture. Gastroenterology 2003;125:1591–7. - PubMed
    1. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254–9. - PMC - PubMed
    1. Taylor BC, Schreiner PJ, Stone KL, et al. Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures. J Am Geriatr Soc 2004;52:1479–86. - PubMed

Publication types

MeSH terms