5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!
- PMID: 16009677
- PMCID: PMC1774874
- DOI: 10.1136/gut.2004.063545
5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!
Abstract
There is growing evidence that 5-HT3 receptor blockade will benefit patients with fatigue. Further research is needed to determine the mechanism underlying this widespread clinically important symptom and therapies may be derived from targeting the 5-HT system.
Comment on
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Effect of ondansetron, a 5-HT3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study.Gut. 2005 Aug;54(8):1169-73. doi: 10.1136/gut.2004.055251. Gut. 2005. PMID: 16009690 Free PMC article. Clinical Trial.
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