Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jul;13(7):624-7.
doi: 10.1176/appi.ajgp.13.7.624.

Heritability of psychosis in Alzheimer disease

Silviu-Alin Bacanu  1 , Bernie Devlin, Kodavali V Chowdari, Steven T DeKosky, Vishwajit L Nimgaonkar, Robert A Sweet
Affiliations

Heritability of psychosis in Alzheimer disease

Silviu-Alin Bacanu et al. Am J Geriatr Psychiatry. 2005 Jul.

Abstract

Objective: The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P.

Methods: The heritability of LOAD+P, defined by single and multiple psychotic symptoms, was estimated with data from the National Institute of Mental Health AD Genetics Initiative.

Results: The estimated heritability for LOAD+P defined by multiple psychotic symptoms was 61%; for LOAD+P defined by any occurrence of psychotic symptoms, it was 30%.

Conclusion: Multiplicity of symptoms may represent a useful means for defining a genetically determined LOAD+P phenotype.

PubMed Disclaimer

Publication types