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Review
. 2005 Jun;22(3):386-99.
doi: 10.1039/b418841c. Epub 2005 Apr 4.

Cucurbitacins and cucurbitane glycosides: structures and biological activities

Jian Chao Chen  1 , Ming Hua Chiu, Rui Lin Nie, Geoffrey A Cordell, Samuel X Qiu
Affiliations
Review

Cucurbitacins and cucurbitane glycosides: structures and biological activities

Jian Chao Chen et al. Nat Prod Rep. 2005 Jun.

Erratum in

  • Nat Prod Rep. 2005 Dec;22(6):794-5

Abstract

The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10-->9beta)-abeo-10alpha-lanost-5-ene (also known as 9beta-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.

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