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Review
. 2005 Oct;164(10):616-20.
doi: 10.1007/s00431-005-1728-6. Epub 2005 Jul 13.

Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review

Yusuke Shiozawa  1 , Nobutaka Kiyokawa, Masahiro Saito, Junichiro Fujimoto, Jun-Ichi Hata, Yuichiro Yamashiro
Affiliations
Review

Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review

Yusuke Shiozawa et al. Eur J Pediatr. 2005 Oct.

Abstract

We report a 2-year-old Japanese boy without bone marrow involvement who developed a primary granulocytic sarcoma in his spinal canal. Tumour cells were positive for myeloperoxidase, MIC2, CD56 and, CD68 on formalin-fixed, paraffin-embedded tissue sections and CD13, CD33, CD45, and CD64 on acetone-fixed fresh frozen sections. Nine months after the initiation of treatment, the tumour had significantly regressed and the patient was able to walk with help.

Conclusion: Our patient is the youngest case of granulocytic sarcoma of the spine without bone marrow involvement. Immunohistochemical methods are very helpful in establishing a diagnosis of granulocytic sarcoma.

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