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Review
. 2005 Jul;5(4):549-59.
doi: 10.1586/14737159.5.4.549.

Miniaturized detection technology in molecular diagnostics

Larry J Kricka  1 , Jason Y Park, Sam F Y Li, Paolo Fortina
Affiliations
Review

Miniaturized detection technology in molecular diagnostics

Larry J Kricka et al. Expert Rev Mol Diagn. 2005 Jul.

Abstract

Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection.

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References

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