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Review
. 2005 Jul;5(4):549-59.
doi: 10.1586/14737159.5.4.549.

Miniaturized detection technology in molecular diagnostics

Larry J Kricka  1 , Jason Y Park, Sam F Y Li, Paolo Fortina
Affiliations
Review

Miniaturized detection technology in molecular diagnostics

Larry J Kricka et al. Expert Rev Mol Diagn. 2005 Jul.

Abstract

Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection.

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References

    1. Fortina P, Kricka LJ, Surrey S, Grodzinski P. Nanobiotechnology: promise and reality of new approaches to molecular recognition. Trends Biotechnol. 23(4), 168–173 (2005). - PubMed
    1. Kricka LJ, Fortina P. Nanotechnology and applications: an all-language literature survey including books and patents. Clin. Chem. 48(2), 662–664 (2002). - PubMed
    1. Kricka LJ (Ed.). The Hitchhiker’s Guide to Analytical Microchips. AACC Press, Washington, DC, USA (2002).

    2. Concise and illustrated guide to the full range of analytical microchips and associated technology.

    1. Cheng J, Kricka LJ (Eds). Biochip Technology. Harwood, PA, USA (2001).
    1. Li J, Stein, D, Qun C et al. Solid state nanopore as a single DNA molecule detector. Biophys. J. 84(2 Pt 2), 134A–135A (2003).

    2. Use of a fabricated nanopore for sequencing.

Websites
    1. Genetic Engineering News www.genengnews.com (Viewed June 2005)
    1. Nanosphere, Inc. www.nanosphere-inc.com (Viewed June 2005)
    1. FDA clears AmpliChip™ Cytochrome P450 Genotyping Test www.fda.gov/bbs/topics/news/2004/new01149.html (Viewed June 2005)
    1. OIVD Requests a Meeting with Roche Diagnostics Regarding the AmpliChip CYP450 Microarray www.fda.gov/cdrh/oivd/letter-roche2.html (Viewed June 2005)
    1. NanoDrop Technologies www.nanodrop.com (Viewed June 2005)
Patent
    1. Natan MJ, Mallouk TE. Assemblies of differentiable segmented particles. US patent appl. 20040209376 (2004).

Publication types

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