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Review
. 2005 Aug;79(15):9369-80.
doi: 10.1128/JVI.79.15.9369-9380.2005.

Stealth and cunning: hepatitis B and hepatitis C viruses

Stefan F Wieland  1 , Francis V Chisari
Affiliations
Review

Stealth and cunning: hepatitis B and hepatitis C viruses

Stefan F Wieland et al. J Virol. 2005 Aug.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Sequential HBV and HCV infection in chimpanzees. Upper panels, two naïve chimpanzees (Ch1558 and Ch1564) were intravenously inoculated with 108 GE of a monoclonal HBV isolate (genotype ayw) contained in pooled serum from HBV transgenic mice as described by Guidotti et al. (58). Lower panels, 22 months after resolution of the acute HBV infection, Ch1558 and Ch1564 were transfected with HCV RNA of genotype 1a as described previously (149). Serum HBV DNA (upper panels) and HCV RNA (lower panels) levels are expressed as percentages of the corresponding peak serum levels (% max).
FIG. 2.
FIG. 2.
Liver gene expression profile during acute HBV and acute and chronic HCV infection in chimpanzees. The HCV and HBV infection protocols and the gene selection criteria are described by Su et al. (142) and Wieland et al. (171), respectively. Briefly, gene expression profiles of virus-induced genes from all three HCV- or HBV-infected animals were required to positively or negatively correlate with viremia with a Pearson's correlation of better than 0.7. Gene expression profiles related to clearance in HCV-infected chimpanzees were identified as described by Su et al. (142), and that list was extended by including genes whose expression correlated with the profiles of the prototype genes RANTES, MIG, TcR and MHC by a Pearson's correlation of better then 0.7 for all three chimpanzees. HBV clearance-related genes were identified as described by Wieland et al. (171). HBV liver DNA levels (blue) and HCV serum RNA levels (green) are presented as percentages of the peak level (% max) for the chimpanzee with the highest peak level of HBV and HCV, respectively.
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