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. 1992 Jan;29(1):73-7.

Serological responses to hepatitis B virus infection in multi-transfused thalassemic children

S Gulati  1 , R K Marwaha, J B Dilawari, U Midha, B N Walia
Affiliations
  • PMID: 1601501

Serological responses to hepatitis B virus infection in multi-transfused thalassemic children

S Gulati et al. Indian Pediatr. 1992 Jan.

Abstract

One hundred children with beta-thalassemia major were studied prospectively. A one time analysis of serum samples was carried out for a battery of hepatitis B viral markers viz., HBsAg, anti-HBs and anti-HBc. Seven mutually different serological patterns were observed. The commonest profile seen in 49 patients was a combined seropositivity for anti-HBc and anti-HBs indicating past HBV infection with persisting immunity. Definite evidence of active HBV infection (seropositivity for HBsAg and/or HBeAg) was demonstrated in 10 cases, six of these were HBsAg positive. Anti-HBc positivity alone was detected in 17 patients. The remaining 24 children were seropositive for anti-HBs alone suggesting a possible passive transmission of anti-HBs through blood transfusion.

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