Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Mar;22(3):129-31.
doi: 10.1007/s10815-005-4878-6.

Down syndrome and precocious menopause

Ana Karina Bartmann  1 , Francielle M Araújo, Odilon Iannetta, João C C Paneto, Lúcia Martelli, Ester Silveira Ramos
Affiliations

Down syndrome and precocious menopause

Ana Karina Bartmann et al. J Assist Reprod Genet. 2005 Mar.

Abstract

Purpose: To determine whether women who had children with Down syndrome (DS) had precocious menopause.

Methods: We selected 104 mothers of children with DS and 121 normal women who had children with no genetic problems. We conducted an interview and compared their mean age at menopause.

Results: We did not detect a statistically significant difference in mean age at menopause. When we stratified into women who had conceived when younger or older than 35 years of age, we found a statistically significant difference only for women who had conceived at the age of 35 years or older. We observed three cases of previous unilateral ovarian surgery in the study group and one case in the control group.

Conclusions: We cannot conclude that mothers of children with DS will have precocious menopause. Nevertheless, our findings do not exclude the theory of reduced ovarian reserve as a primordial factor in the genesis of DS.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Saenz RB. Primary care of infants and young children with Down Syndrome. Am Fam Physician. 1999;59:392–395. - PubMed
    1. Newberger DS. Down Syndrome: Prenatal risk assessment and diagnosis. Am Fam Physician. 2000;62:825–838. - PubMed
    1. Jorde LB, Carey JC, White RL. Clinical cytogenetics: The chromosome basis of human disease. In: Jorde LB, Carey JC, White RL, editors. Medical Genetics. St. Louis: Mosby; 1995. p. 102.
    1. Warburton D. The effect of maternal age on the frequency of trisomy: change in meiosis or in utero selection? In: Hassold TJ, Epstein CJ, editors. Molecular and Cytogenetic Studies of Non-disjunction. New York: Liss; 1989. pp. 165–81. - PubMed
    1. Little BB, Ramin SM, Cambridge BS, Schneider NR, Cohen DS, Snell LM, Harrod MJ, Johnston WL. Risk of chromosomal abnormalities with emphasis on liveborn in offspring of very young mothers. Am J Hum Genet. 1995;57:1178. - PMC - PubMed

Publication types