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. 2005 Jul 22;70(15):6105-7.
doi: 10.1021/jo050591h.

Practical preparation of 3,3-difluoropyrrolidine

Feng Xu  1 , Bryon Simmons, Joseph Armstrong 3rd, Jerry Murry
Affiliations

Practical preparation of 3,3-difluoropyrrolidine

Feng Xu et al. J Org Chem. .

Abstract

A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH(3).Me(2)S reduction.

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