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. 2005 Sep 1;15(17):3896-9.
doi: 10.1016/j.bmcl.2005.05.111.

Cyclic urea derivatives as potent NK1 selective antagonists

Ho-Jane Shue  1 , Xiao Chen, Neng-Yang Shih, David J Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H Schwerdt, Sapna Shah, Gregory A Reichard, John J Piwinski, Ruth A Duffy, Jean E Lachowicz, Vicki L Coffin, Fei Liu, Amin A Nomeir, Cynthia A Morgan, Geoffrey B Varty
Affiliations

Cyclic urea derivatives as potent NK1 selective antagonists

Ho-Jane Shue et al. Bioorg Med Chem Lett. .

Abstract

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

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