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Case Reports
. 2005 Jun;46(6):925-7.
doi: 10.1080/10428190500052248.

Therapy-related acute lymphoblastic leukemia with MLL rearrangement following treatment of Burkitt's leukemia

Frederic Millot  1 , Francoise Brizard, Nathalie Sorel, Claude Preudhomme, Marie Cividin, Francois Guilhot, Andre Brizard
Affiliations
Case Reports

Therapy-related acute lymphoblastic leukemia with MLL rearrangement following treatment of Burkitt's leukemia

Frederic Millot et al. Leuk Lymphoma. 2005 Jun.

Abstract

The occurrence of therapy-related acute lymphoblastic leukemia (ALL) is rare and, to our knowledge, is not reported in patients treated for Burkitt's leukemia. We report on a child with ALL with translocation t(4;11)(q21;q23) involving the MLL gene, 13 months after chemotherapy for Burkitt's leukemia. This present observation indicates that caution should be exercised in using high cumulative doses of DNA topoisomerase II inhibitors in such patients.

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