Kimura's disease: two case reports with a review of the literature

Abstract

Kimura's disease is an uncommon, chronic inflammatory disorder of unknown etiology. The disease usually presents as a massive subcutaneous swelling with predilection for the head and neck region in young men. Morphologically, the lesions are characterized with lymphoid follicles, intensive aggregations of eosinophils, vascular proliferation and fibrosis. Laboratory analyses detect hypereosinophilia and elevated total IgE in the blood. We present two cases of Kimura's disease in which lymphadenopathy and cutaneous nodules were the main findings. We reviewed the literature on Kimura's disease.