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. 2005 Jul;11(7):1118-20.
doi: 10.3201/eid1107.041237.

Blackwater fever in children, Burundi

Federico Gobbi  1 , Sabrina Audagnotto, Laura Trentini, Innocent Nkurunziza, Manuel Corachan, Giovanni Di Perri
Affiliations

Blackwater fever in children, Burundi

Federico Gobbi et al. Emerg Infect Dis. 2005 Jul.

Abstract

Blackwater fever is characterized by acute intravascular hemolysis with hemoglobinuria in patients with Plasmodium falciparum malaria. Its pathogenesis and management are still debated. Nine cases of this syndrome occurred in 2003 at Kiremba Hospital in Burundi in children receiving multiple quinine treatments.

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References

    1. Bruce-Chwatt LJ. Quinine and the mystery of blackwater fever. Acta Leiden. 1987;55:181–96. - PubMed
    1. White NJ. Malaria. In: Cook GC, Zumla AI, editors. Manson's tropical diseases. XXI ed. Philadelphia: W.B. Saunders; 2003. p. 1205–95.
    1. Bruneel F, Gachot B, Wolff M, Regnier B, Danis M, Vachon F, et al. Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. Clin Infect Dis. 2001;32:1133–40. 10.1086/319743 - DOI - PubMed
    1. Van den Ende J, Coppens G, Verstraeten T, Van Haeghenborgh T, Depraetere K, Van Gompel A, et al. Recurrence of blackwater fever: triggering of relapses by different antimalarials. Trop Med Int Health. 1998;3:632–9. 10.1046/j.1365-3156.1998.00287.x - DOI - PubMed
    1. Bisoffi Z, Marocco S, Montero G, Marsiaj M. Acute intravascular haemolysis (blackwater fever) after malarial treatment. Trop Med Int Health. 1999;4:72–3. - PubMed

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