Review
doi: 10.1152/physiol.00004.2005.
Mechanical signals, IGF-I gene splicing, and muscle adaptation
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- PMID: 16024511
- DOI: 10.1152/physiol.00004.2005
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Review
Mechanical signals, IGF-I gene splicing, and muscle adaptation
Physiology (Bethesda).
2005 Aug.
Free article
Abstract
Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). Following resistance exercise, MGF "kick starts" muscle hypertrophy and is important in local tissue repair. Loss of muscle mass in old age and certain diseases is associated with an impaired ability to express MGF.
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