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Case Reports
. 2005 Aug;76(8):1115-20.
doi: 10.1136/jnnp.2003.035428.

Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin

M Odaka  1 , M Tatsumoto, K Susuki, K Hirata, N Yuki
Affiliations
Case Reports

Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin

M Odaka et al. J Neurol Neurosurg Psychiatry. 2005 Aug.

Abstract

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a heterogeneous disorder and both clinical course and response to treatment vary widely. Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. There is no consensus regarding this in the published literature.

Present report: A patient with CIDP was treated with oral prednisolone and cyclophosphamide pulse therapy but required repeated plasma exchange and intravenous immunoglobulin (IVIg). Treatment with ciclosporin freed the patient from repeated IVIg administration. Therapeutic responses in 14 subsequent cases including three patients who showed improvement with ciclosporin are also presented along with an algorithm of the authors' suggested protocol for treatment.

Conclusion: Ciclosporin should be considered for patients with intractable CIDP who require repeated IVIg.

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