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. 2005 Oct;31(2):223-7.
doi: 10.1007/s11262-005-1799-5.

Distribution of latent herpes simplex virus type-1 and varicella zoster virus DNA in human trigeminal Ganglia

Randall J Cohrs  1 , James J Laguardia, Donald Gilden
Affiliations

Distribution of latent herpes simplex virus type-1 and varicella zoster virus DNA in human trigeminal Ganglia

Randall J Cohrs et al. Virus Genes. 2005 Oct.

Abstract

Trigeminal ganglia removed at autopsy from immunocompetent individuals without cutaneous signs of herpesvirus infection were fixed, cut into 5-microm sections, and screened at 100-microm intervals (20 adjacent sections) by PCR for latent herpes simplex type 1(HSV-1) and varicella zoster virus (VZV) DNA. Sections that contained >5 neurons with nuclei stained by hematoxylin/eosin revealed HSV-1 DNA in most samples and VZV DNA in approximately 50% of samples. HSV-1 and VZV DNA were distributed throughout each latently infected ganglion.

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