Imaging and other biomarkers in early clinical studies: one step at a time or re-engineering drug development?
- PMID: 16027435
- DOI: 10.1200/JCO.2005.05.907
Imaging and other biomarkers in early clinical studies: one step at a time or re-engineering drug development?
Comment on
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Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results.J Clin Oncol. 2005 Aug 20;23(24):5474-83. doi: 10.1200/JCO.2005.04.192. Epub 2005 Jul 18. J Clin Oncol. 2005. PMID: 16027439 Clinical Trial.
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Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study.J Clin Oncol. 2005 Aug 20;23(24):5464-73. doi: 10.1200/JCO.2005.04.143. Epub 2005 Jul 18. J Clin Oncol. 2005. PMID: 16027440 Clinical Trial.
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