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. 1992:6 Suppl 3:166S-167S.

The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

A Rosato  1 , V Bronte, F Pollis, S Mandruzzato, A Zambon, P Zanovello, D Collavo
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  • PMID: 1602816

The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

A Rosato et al. Leukemia. 1992.

Abstract

The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interfering with CTL generation and localization in the tumor mass.

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