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. 2005 Jul 20:3:48.
doi: 10.1186/1477-7819-3-48.

Management of renal cell carcinoma with solitary metastasis

Yuvaraja B Thyavihally  1 , Umesh Mahantshetty, Ravichand S Chamarajanagar, Srinivas G Raibhattanavar, Hemant B Tongaonkar
Affiliations

Management of renal cell carcinoma with solitary metastasis

Yuvaraja B Thyavihally et al. World J Surg Oncol. .

Abstract

Background: Distant metastasis are common in Renal cell carcinoma (RCC) nearly one forth of the patients have metastasis at presentation while another 50% develop metastasis during the follow-up. A small percentage of these are solitary metastasis. We describe survival after surgical excision or radiotherapy of solitary metastatic lesion from renal cell carcinoma.

Patients and methods: Between 1988-2001, 43 patients with solitary metastasis to different sites from renal cell carcinoma underwent either surgical excision or radiotherapy were analyzed. The solitary nature of the lesions was confirmed by investigations. All patients have had radical nephrectomy for the primary lesion. Survival analysis was carried out by Kaplan Meier Method.

Results: All solitary metastatic lesions were treated with intent of cure either by excision or radiotherapy. Of these, 13 patients had solitary metastasis at the time of presentation in whom 3-year overall median survival was 26 months. The survival of those who developed solitary metastases during follow-up after nephrectomy for primary was 45 months. The patients with long interval between diagnosis and development of metastasis, early stage and low grade of the primary tumor had better prognosis.

Conclusion: Complete resection of either synchronous or metachronous solitary metastases from renal cell carcinoma is justified and can contribute to a long-term survival in this select group of patients.

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Figures

Figure 1
Figure 1
Overall survival in patients with synchronous solitary metastasis.
Figure 2
Figure 2
Ultrasonography showing solitary metachronous metastasis to gall bladder.
Figure 3
Figure 3
Overall survival of the patients with metachronous solitary metastasis.
Figure 4
Figure 4
Overall survival comparing patients with metachronous solitary metastasis occurring within 12 months versus those occurring after 12 months.
Figure 5
Figure 5
Overall survival according to pathologic stage of the primary tumor.
Figure 6
Figure 6
Overall survival according to Fuhrman's nuclear grading.
See this image and copyright information in PMC

References

    1. Matveev VB, Gurarii LL, Began-Bogatskii KM. Surgical treatment of late metastases of kidney cancer. Urol Nefrol (Mosk) 1999;2:51–52. - PubMed
    1. Cozzoli A, Milano S, Cancarini G, Zanotelli T, Cosciani Cunio S. Surgery of lung metastases in renal cell carcinoma. Br J Urol. 1995;75:445–447. - PubMed
    1. Kollender Y, Bickels J, Price WM, Kellar KL, Chen J, Merimsky O, Meller I, Malawer MM. Metastatic renal cell carcinoma of bone: indications and technique of surgical intervention. J Urol. 2000;164:1505–1508. doi: 10.1097/00005392-200011000-00011. - DOI - PubMed
    1. Ritchie AWS, Chisholm GD. The natural history of renal carcinoma. Semin Oncol. 1983;10:390–400. - PubMed
    1. Andoh H, Kurokawa T, Yasui O, Shibata S, Sato T. Resection of a solitary pancreatic metastasis from renal cell carcinoma with a gallbladder carcinoma: report of a case. Surg Today. 2004;34:272–275. doi: 10.1007/s00595-003-2680-6. - DOI - PubMed

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