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. 1992 May;233(1-2):327-30.
doi: 10.1007/BF00587597.

The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription

H Yoshimoto  1 , M Ohmae, I Yamashita
Affiliations

The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription

H Yoshimoto et al. Mol Gen Genet. 1992 May.

Abstract

We have cloned GAM2, which is required for transcription of STA1, a gene encoding an extracellular glucoamylase in Saccharomyces cerevisiae var. diastaticus. DNA sequence analysis revealed that GAM2 is the same gene as SIN3, known to be a general negative regulator of yeast genes. RNA blot analysis indicated that GAM2/SIN3 also acts as a positive regulator of GAM3/ADR6, which in turn is required for transcription of STA1 and ADH2. These results suggest that GAM2 regulates STA1 expression through transcriptional activation of GAM3 and indicate that GAM2/SIN3 protein is a transcriptional regulator that can play a role in both activation and repression of transcription.

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