Review
doi: 10.1212/01.wnl.0000171957.90640.b5.
Epub 2005 Jul 20.
What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports
Affiliations
- PMID: 16033990
- DOI: 10.1212/01.wnl.0000171957.90640.b5
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Review
What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports
Neurology.
.
Abstract
Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.
Comment in
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Assessing the risk of a necessary harm: placebo surgery in Parkinson disease.Neurology. 2005 Oct 11;65(7):982-3. doi: 10.1212/01.wnl.0000182818.15330.b9. Neurology. 2005. PMID: 16217047 No abstract available.
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What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports.Neurology. 2006 Jun 13;66(11):1788-9; author reply 1788-9. doi: 10.1212/01.wnl.0000230564.67320.b1. Neurology. 2006. PMID: 16769977 Review. No abstract available.
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