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Review
. 2005 Apr;26(3):179-88.
doi: 10.1385/endo:26:3:179.

Structural biology of glycoprotein hormones and their receptors

Qing R Fan  1 , Wayne A Hendrickson
Affiliations
Review

Structural biology of glycoprotein hormones and their receptors

Qing R Fan et al. Endocrine. 2005 Apr.

Abstract

Glycoprotein hormones regulate reproduction in vertebrates and exert their actions through specific G protein-coupled receptors on target cell surfaces. Structural information is now available for human chorionic gonadotropin (CG), follicle-stimulating hormone (FSH), and FSH bound to the extracellular binding domain of its receptor (FSHR(HB)). The recently determined structure of a human FSH-FSHR(HB) complex provides an explanation for the specificity of glycoprotein hormones binding to their receptors, and it suggests hypotheses concerning the mechanism of transmembrane signal transduction.

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References

    1. Nature. 1994 Mar 17;368(6468):251-5 - PubMed
    1. Biol Reprod. 2003 Dec;69(6):1765-70 - PubMed
    1. Vitam Horm. 2002;64:249-322 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):760-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2041-5 - PubMed

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