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. 2004 Dec;1(4):171-5.
doi: 10.1007/s11897-004-0005-8.

Aldosterone in heart failure: pathophysiology and treatment

Allan D Struthers  1
Affiliations

Aldosterone in heart failure: pathophysiology and treatment

Allan D Struthers. Curr Heart Fail Rep. 2004 Dec.

Abstract

Aldosterone produces adverse effects on the vasculature (endothelial dysfunction) and on the myocardium (myocardial fibrosis). These effects have adverse clinical consequences that result in increases in deaths caused by sudden death and by progressive heart failure. The Randomized Aldactone Evaluation Study and the Eplerenone Post-acute Myocardial Infarction Heart Failure Efficacy and Survival Study show this clearly. Aldosterone blockade should become a regular third neuroendocrine-blocking drug in patients with chronic heart failure.

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References

    1. Hypertension. 1998 Jan;31(1 Pt 2):451-8 - PubMed
    1. N Engl J Med. 2003 Apr 3;348(14):1309-21 - PubMed
    1. Am J Cardiol. 1995 Dec 15;76(17):1259-65 - PubMed
    1. Cardiovasc Res. 1997 Jul;35(1):30-4 - PubMed
    1. Circulation. 2003 Oct 14;108(15):1831-8 - PubMed

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