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Review
. 2005 Apr;11(2):129-37.
doi: 10.1080/13550280590922793.

Olfactory transmission of neurotropic viruses

Isamu Mori  1 , Yukihiro Nishiyama, Takashi Yokochi, Yoshinobu Kimura
Affiliations
Review

Olfactory transmission of neurotropic viruses

Isamu Mori et al. J Neurovirol. 2005 Apr.

Abstract

Olfactory receptor neurons are unique in their anatomical structure and function. Each neuron is directly exposed to the external environment at the site of its dendritic nerve terminals where it is exposed to macromolecules. These molecules can be incorporated into by olfactory receptor neurons and transported transsynaptically to the central nervous system. Certain neurotropic pathogens such as herpes simplex virus and Borna disease virus make use of this physiological mechanism to invade the brain. Here the authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health.

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