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Comparative Study
. 2005 Jul;11(3):292-8.
doi: 10.1080/13550280590953799.

Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus

Ann B Ragin  1 , Ying Wu, Pippa Storey, Bruce A Cohen, Robert R Edelman, Leon G Epstein
Affiliations
Comparative Study

Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus

Ann B Ragin et al. J Neurovirol. 2005 Jul.

Abstract

Diffusion tensor imaging (DTI) was used to derive in vivo tissue status measurements of subcortical brain regions that are vulnerable to injury in human immunodeficiency virus (HIV)-infected patients. Quantitative measurements, including the mean diffusivity (MD) and fractional anisotropy (FA), were determined in lateralized basal ganglia (caudate and putamen) and centrum semiovale in 11 well-characterized HIV patients and in 11 control subjects. DTI measurements were examined for patterns of relationship with markers of clinical and cognitive progression. DTI measures acquired in subcortical regions were significantly correlated with loss of function in specific cognitive domains. Significant relationships were identified between measures for putamen and verbal memory (MD), visual memory (FA), working memory (FA), and overall cognitive impairment (MD). Measures for caudate (FA) were significantly correlated with visual memory. Measures for centrum semiovale were significantly correlated with visual memory deficits (MD) and visuoconstruction (FA). Relationships between anisotropy measures and anemia (basal ganglia) and CD4 counts (centrum semiovale) were also observed. Findings from this investigation indicate that DTI is a sensitive tool for correlating neuroanatomic pathologic features with specific cognitive deficits in patients with HIV infection.

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Figures

Figure 1
Figure 1
This axial slice through interventricular foramen shows the largest area of putamen and caudate nuclei. Uniform sized ROIs were placed on the anatomical T2-weighted image and projected on FA and MD maps to obtain DTI values.
Figure 2
Figure 2
ROIs for centrum semiovale were placed on an axial slice above the bilateral ventricles.
See this image and copyright information in PMC

References

    1. An H, Chen Y, Smith KJ, Hall C, Robertson K, Wilber K, Robertson W, Kwock L, Lin W. Whole brain fractional anisotropy analysis in HIV patients with elastic registration. [Abstract]. International Society of Magnetic Resonance in Medicine; 2483, Kyoto, Japan. May 2004.2004.
    1. Avison MJ, Nath A, Berger JR. Understanding pathogenesis and treatment of HIV dementia: a role for magnetic resonance. Trends Neurosci. 2002;25:468–473. - PubMed
    1. Aylward EH, Brettschneider PD, McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, Barta PE, Tien AY, Pearlson GD. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am J Psychiatry. 1995;152:987–994. - PubMed
    1. Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B. 1996;111:209–219. - PubMed
    1. Bell JE. The neuropathology of adult HIV infection. Rev Neurol. 1998;154:816–829. - PubMed

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