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Comment
. 2005 Sep 1;567(Pt 2):359-60.
doi: 10.1113/jphysiol.2005.094474. Epub 2005 Jul 21.

Aminoglycoside ototoxicity: permeant drugs cause permanent hair cell loss

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Comment

Aminoglycoside ototoxicity: permeant drugs cause permanent hair cell loss

J R Waguespack et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1. Schematic representation of proposed mechanism for DHS accumulation in sensory hair cells
DHS enters through mechanotransducer channels and accumulates because entry requires less energy than exit. The enlarged channel shows DHS size relative to estimated channel size (Farris et al. 2004) showing that indeed the molecule can fit through the channel.

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References

    1. Farris HE, LeBlanc CL, Goswami J, Ricci AJ. J Physiol. 2004b;558:769–792. - PMC - PubMed
    1. Jaramillo F, Hudspeth AJ. Neuron. 1991;7:409–420. - PubMed
    1. Jaramillo F, Hudspeth AJ. Proc Natl Acad Sci U S A. 1993;90:1330–1334. - PMC - PubMed
    1. Kroese AB, Das A, Hudspeth AJ. Hear Res. 1989;37:203–217. - PubMed
    1. Marcotti W, van Netten SM, Kros CJ. J Physiol. 2005;567:505–521. - PMC - PubMed

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